IP: Luis Bujanda Fernández de Piérola

Resumen del proyecto: The excessive consumption of alcohol represents an important health and economical problem in our country. It is thought that between 2% and 20% of Spanish population are excessive consumers of alcohol. The factors that determine that an individual consumes excessive alcohol form are fundamentally two: genetic and environmental. Knowing genetic determinants and environmental factors related to the excessive consumption of alcohol can help us to realize programs of primary prevention of alcoholism and, as well, to avoid problems derived from an excessive consumption of alcohol.
The aim is to value if determined polymorphisms genetic and environmental factors are associated with an excessive consumption of alcohol. For it, a type cases - controls study will be realized, in which genetic polymorphisms would be studied in individuals selected from EPIC program with consumption in men major to 70 grams of alcohol/day and 42 grams/day in women. The control group will be formed by abstemious people, couplet by age and sex.
Would be studied the genetic polymorphisms (both detoxification and addiction) until now involved in the excessive consumption of alcohol (ADH2, ADH3, ALDH2 y CYP2E1, TH, VTM2 o SLC18A2, DAT o SLC6A3, DRD1-5, MAOA, COMT, MTHFR y RCF1) and environmental factors that can be related (like consumption tobacco, diet, exercise, socioeconomic level, consumption of medicaments and obesity).

Entidad financiadora: FUNDACIÓN VASCA DE INNOVACIÓN E INVESTIGACIÓN SANITARIA (BIOEF)