IP: Dr. Andrés C. García Montero

Resumen del proyecto: The study aims to clarify the potential immunomodulatory role that pathologic mast cell (MC) from different systemic mastocytosis (SM) patients would have over other cell types of the innate and/or adaptive immune responses, and to know whether such interactions could have any role on the clinicbiological features and progression of the disease. To achieve that goal a detailed immunecharacterization (by multiparametric flow cytometry) of the different cell compartments of the innate and adaptive immune responses has been performed within both peripheral blood and bone marrow samples from patients with different subtypes (indolent vs advanced/aggressive forms) of SM. As a distribution of dendritic monocyte cell populations was altered in individuals with systemic mastocytosis respect to the distribution in healthy adults, the need arises to study whether these changes affect the function and activation state of these populations. Thus, the study for the detection of the soluble levels of the EMR2 monocyte activation marker in plasma of patients by ELISA immunoassay would serve as a method of confirmation of the results obtained so far with the partial development of the project where an alteration of the immune system is observed in these patients, especially in the previously mentioned populations.

Entidad financiadora: Ministerio de Ciencia, Innovación y Universidades