IP: Dr. David González de Olano

Resumen del proyecto: Vasospasm of epicardial coronary arteries due to increased inflammatory mediators that are released during underlaying allergic event, also known as Kounis syndrome, is a disease entity of increasing diagnosis. It has been usually described from the allergological point of view because is a condition associated with mast cell activation, such as allergy, hypersensitivity and anaphylactic or anaphylactoid insult. Nevertheless, little is known about association between Kounis and Mast Cell Activation Syndrome (MCAS), other entity/s driven by mast cell and presented with anaphylaxis. Nowadays, basal serum tryptase level is the better marker to evaluate mast cell activation. Recent studies have suggested an association between MCAS and presence of hereditary alpha tryptasemy (HAT). As HAT has been shown to cause raised basal serum tryptase levels as compared to levels found within (healthy) general population, this genetic variant would represent a (potentially) good candidate factor to be linked to higher risk of developing Kounis Syndrome. This study was conducted by clinicians involved in the Spanish Network on Mastocytosis (Red Española de Mastocitosis, REMA), who were involved in diagnosis, treatment and clinical follow-up of patients with mast cell related diseases.

Entidad financiadora: Instituto Ramón y Cajal de Investigación Sanitaria