IP: Carlos Flores Infante

Resumen del proyecto: Identifying the genetic variants underlying susceptibility constitutes the first necessary step towards the understanding of asthma causes and for their clinical application in diagnosis. The complexity of this disease and the inability to explain its genetic component by means of the risk alleles determined to date, support that many asthma susceptibility genes remain to be identified. This proposal aims
to identify the genetic variants involved in asthma susceptibility by conducting a two-stage genome-wide association study that will analyze more than 6.5 million polymorphisms in DNA samples from 1,265 asthma cases and 1,796 controls of Spanish ancestry. In addition, the results will be integrated with the interactome
information, which will allow identifying novel asthma susceptibility genes and to improve our understanding of the biological processes involved in the disease development. In the first stage (i.e. genomic), the study has identified more tan twenty regions of potential interest. A validation stage in independent samples will be necessary for the identification of novel genetic regions for asthma susceptibility.

Entidad financiadora: Instituto de Salud Carlos III